Vaccine Protocols

Information and templates for writing a vaccine administration order, also called a protocol.

Subscribe to Vaccine Protocols to receive an email every time a protocol is updated or added to the page.

On this page:

Guidance documents

• Guidance for Adopting Vaccine Protocols (PDF)
  Information on why vaccine protocols are necessary, why there are so many protocols, annual signing of protocols, and how to get started.
• AAP: Recommended Child and Adolescent Immunization Schedule for Ages 18 Years or Younger (PDF)
• AAFP: Adults 19 and Older Immunization Schedule
• ACOG: Maternal Immunization Schedule
  Summary of routinely recommended maternal vaccines.

Supporting resources

• FDA: Vaccines Licensed for Use in the United States
• Immunize.org: Clinical Resources: A-Z
• American Academy of Pediatrics Red Book: 2024–2027 Report of the Committee on Infectious Diseases
• The Vaccine Handbook: A Practical Guide for Clinicians (“The Purple Book”)
  A comprehensive source of practical, up-to-date information for vaccine providers, educators, and advocates.
• Institute for Vaccine Safety: Excipients in Routinely Recommended Vaccines
  List of all ingredients included in U.S. vaccines, by vaccine, to help determine potential allergens.

Vaccine protocol templates

Vaccine protocol templates to be filled in and used.

COVID-19

• 2025-26 Moderna COVID-19 Vaccine Protocol for Age 6 Months through 4 Years (Word) Updated 09/23/25
• 2025-26 COVID-19 Vaccine Protocol for Age 5 to 11 Years (Word) Updated 09/23/25
• 2025-26 COVID-19 Vaccine Protocol for Age 12 Years and Older (Word) Updated 09/23/25

DTaP

• Diphtheria, Tetanus, and Pertussis (DTaP) Routine and Catch-up Vaccine Protocol (Word) Updated 03/26/24

DTap-IPV

• Combination Diphtheria, Tetanus, and Pertussis - Polio (DTap-IPV) Vaccine Protocol (Word) Updated 03/26/24

DTaP-IPV-Hep B

• Combination Diphtheria, Tetanus, and Pertussis - Polio - Hepatitis B (DTaP-IPV-HepB) Routine and Catch-up Vaccine Protocol (Word) Updated 03/26/24

DTap-IPV-Hib

• Combination Diphtheria, Tetanus, and Pertussis - Polio - Haemophilus influenza, Type B (DTap-IPV-Hib) Routine and Catch-up Vaccine Protocol (Word) Updated 03/26/24

DTaP-IPV-Hib-Hep B

• Combination Diphtheria, Tetanus and Pertussis – Polio – Haemophilus influenza, type B – Hepatitis B (DTaP-IPV-Hib-HepB) Routine and Catch-up Vaccine Protocol (Word) Updated 03/26/24

Hepatitis A

• Hepatitis A (Hep A) Routine, Catch-up and At-risk Vaccine Protocol (Word) Updated 06/06/23

Hepatitis A and Hepatitis B (Twinrix)

• Hepatitis A and Hepatitis B as Twinrix Vaccine Protocol (Word) Updated 12/17/24

Hepatitis B

• Hepatitis B (Hep B) Routine Infant Vaccine Protocol (Word) Updated 06/06/23
• Hepatitis B (Hep B) Catch-up Vaccine Protocol (Word) Updated 12/17/24
• Hepatitis B (Hep B) Adult Vaccine Protocol (Word) Updated 12/17/24

Hib

• Haemophilus Influenza, Type B (Hib) Routine and Catch-up Vaccine Protocol (Word) Updated 06/06/23

HPV

• Human Papillomavirus Routine and Catch-up Vaccine Protocol (Word) Updated 06/06/23

Influenza

• Inactivated Influenza Vaccine (IIV) Protocol Age 6 Months Through 8 Years (Word) Updated 08/20/26
• Inactivated (IIV) and Messenger RNA (mRNA) Influenza Vaccine Protocol Age 9 Years and Older (Word) Updated 08/20/26
• Live Attenuated Influenza Vaccine (LAIV) Vaccine Protocol Age 2 Through 49 Years (Word) Updated 08/20/26

Meningococcal

• Meningococcal B Vaccine Protocol (Word) Updated 11/05/24
• Meningococcal ABCWY Vaccine Protocol (Word) Updated 07/29/25
• Meningococcal Conjugate Vaccine, 4-Valent (MCV4) for Routine, Catch-up, At-risk and Booster Dose Vaccine Protocol (Word) Updated 06/06/23

MMR and MMRV

• MMR Routine and Catch-up Vaccine Protocol (Word) Updated 06/03/25
• Combination Measles, Mumps, Rubella, and Varicella (MMRV) Routine and Catch-up Vaccine Protocol (Word) Updated 06/06/23

Orthopox (mpox)

• Orthopox Vaccine Protocol: JYNNEOS Updated 08/26/24

Pneumococcal

• Pneumococcal Conjugate, 15-valent (PCV15) Routine, Catch-up & At-Risk Vaccine Protocol for Persons 6 Weeks to Age 18 Years (Word) Updated 02/20/25
• Pneumococcal Conjugate Vaccine, 15-Valent (PCV15) Vaccination: Vaccine Protocol for Persons Age 19 or Older (Word) Updated 11/05/24
• Pneumococcal Conjugate, 20-valent (PCV20) Routine, Catch-up & At-Risk Vaccine Protocol for Persons 6 Weeks to Age 18 Years (Word) Updated 09/28/23
• Pneumococcal Conjugate Vaccine, 20-Valent (PCV20) Vaccination: Vaccine Protocol for Persons Age 19 Years or Older (Word) Updated 11/05/24
• Pneumococcal Conjugate Vaccine, 21-Valent (PCV21) Vaccination: Vaccine Protocol for Persons Age 19 Years or Older (Word) Updated 11/05/24
• Pneumococcal Polysaccharide Vaccine, 23-Valent (PPSV23) Vaccination: Vaccine Protocol for Persons Age 19 Years or Older (Word) Updated 11/05/24
• Pneumococcal Polysaccharide Vaccine, 23-Valent (PPSV23) Vaccination: Vaccine Protocol for At-risk Persons Age 2-18 Years (Word) Updated 04/28/22

Polio

• Inactivated Polio Vaccine (IPV) for Routine, Catch-up and Booser Dose Vaccine Protocol (Word) Updated 04/18/24

Rotavirus

• Rotavirus Routine and Catch-up Vaccine Protocol (Word) Updated 06/06/23

RSV

• Respiratory Syncytial Virus (RSV) Monoclonal Antibody (RSV-mAb) Protocol (Word) Updated 03/16/26
  Administration of nirsevimab and clesrovimab are typically recommended October through March, but the timing of the onset and duration of the RSV season may vary. Refer to Health Advisory: Health Advisory: MDH Extends Date for Use of RSV Monoclonal Antibodies Through April 30, 2026 (PDF), for guidance on changes to immunization recommendations related to RSV seasonality.
• Respiratory Syncytial Virus (RSV) Vaccine Protocol (Word) Updated 08/28/25

Tdap and Td

• Tetanus and Diphtheria (Td) Vaccine Protocol for Children Less Than Age 7 with Contraindication to Pertussis-containing Vaccine (Word) Updated 03/26/24
• Tetanus and Diphtheria Toxoids and Acellular Pertussis (Tdap) and Tetanus and Diphtheria (Td) Routine, Catch-up and Booster Dose Vaccine Protocol (Word) Updated 06/06/23

Varicella and MMRV

• Varicella Routine, Catch-up and Post Exposure Prophylaxis Vaccine Protocol (Word) Updated 06/06/23
• Combination Measles, Mumps, Rubella, and Varicella (MMRV) Routine and Catch-up Vaccine Protocol (Word) Updated 06/06/23

Zoster

• Recombinant Zoster Vaccine (RZV) Routine and At-risk Vaccine Protocol (Word) Updated 06/06/23